{"id":853,"date":"2018-01-26T17:15:14","date_gmt":"2018-01-26T08:15:14","guid":{"rendered":"https:\/\/wp.bs-lab.ks.service.cloud.teu.ac.jp\/?page_id=853"},"modified":"2019-11-15T14:17:58","modified_gmt":"2019-11-15T05:17:58","slug":"research-2","status":"publish","type":"page","link":"https:\/\/yoshida-lab.bs.teu.ac.jp\/?page_id=853&lang=en","title":{"rendered":"Research"},"content":{"rendered":"<h2>Development of DNA methylation level sensing system for home cancer diagnostics<\/h2>\n<p>DNA methylation at the 5\u2032-position of cytosine in CpG dinucleotides has important roles in regulation of gene expression. Gene-specific DNA and global DNA methylation levels have been considered as biomarkers for cancer diagnostics. We therefore currently have several projects to develop simple DNA methylation detection systems to be applied for simple cancer diagnostics.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-914\" src=\"https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2018\/01\/BRET_English-01.jpg\" alt=\"\" width=\"3058\" height=\"1947\" srcset=\"https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2018\/01\/BRET_English-01.jpg 3058w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2018\/01\/BRET_English-01-300x191.jpg 300w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2018\/01\/BRET_English-01-768x489.jpg 768w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2018\/01\/BRET_English-01-1024x652.jpg 1024w\" sizes=\"auto, (max-width: 3058px) 100vw, 3058px\" \/><\/p>\n<p>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2223\" src=\"https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/180219_PCR_English-01-scaled.jpg\" alt=\"\" width=\"2560\" height=\"1722\" srcset=\"https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/180219_PCR_English-01-scaled.jpg 2560w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/180219_PCR_English-01-300x202.jpg 300w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/180219_PCR_English-01-768x517.jpg 768w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/180219_PCR_English-01-1536x1033.jpg 1536w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/180219_PCR_English-01-2048x1378.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<h2>Functional analysis of non-canonical DNA structures in genomic DNA<\/h2>\n<p>DNA quadruplex structures are one of the non-canonical DNA structure that were found in genomic DNA; however, little is known about the biological functions. We are aiming to identify DNA quadruplex structures on genomic DNA by next generation sequencers and reveal the biological functions.<\/p>\n<p>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2221\" src=\"https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/WGA-1.jpg\" alt=\"\" width=\"2141\" height=\"2096\" srcset=\"https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/WGA-1.jpg 2141w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/WGA-1-300x294.jpg 300w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/WGA-1-768x752.jpg 768w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/WGA-1-1536x1504.jpg 1536w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/WGA-1-2048x2005.jpg 2048w\" sizes=\"auto, (max-width: 2141px) 100vw, 2141px\" \/><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2219\" src=\"https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/CD.jpg\" alt=\"\" width=\"1930\" height=\"1066\" srcset=\"https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/CD.jpg 1930w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/CD-300x166.jpg 300w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/CD-768x424.jpg 768w, https:\/\/yoshida-lab.bs.teu.ac.jp\/wp-content\/uploads\/2019\/11\/CD-1536x848.jpg 1536w\" sizes=\"auto, (max-width: 1930px) 100vw, 1930px\" \/><\/p>\n<p>\u00a0<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"blob:https:\/\/yoshida-lab.bs.teu.ac.jp\/7c905bb0-6c50-49bc-a4df-d2c2a6824e49\" alt=\"\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Development of DNA methylation level sensing system for home cancer diagnostics DNA methylation at the 5\u2032-posi [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"sns_share_botton_hide":"","vkExUnit_sns_title":"","_vk_print_noindex":"","sitemap_hide":"","vkExUnit_sitemap":"","vkExUnit_EyeCatch_disable":"","_veu_custom_css":"","veu_display_promotion_alert":"","_exclude_from_list_pages":"","vkexunit_cta_each_option":"","vkExUnit_childPageIndex":"","vkExUnit_pageList_ancestor":"","vkExUnit_contact_enable":"","twitterCardType":"summary","cardImageID":0,"cardImage":"","cardTitle":"","cardDesc":"","cardImageAlt":"","cardPlayer":"","cardPlayerWidth":0,"cardPlayerHeight":0,"cardPlayerStream":"","cardPlayerCodec":"","_lightning_design_setting":[],"footnotes":""},"categories":[],"tags":[],"class_list":["post-853","page","type-page","status-publish","hentry"],"veu_head_title_object":{"title":"","add_site_title":""},"_links":{"self":[{"href":"https:\/\/yoshida-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/853","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/yoshida-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/yoshida-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/yoshida-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/yoshida-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=853"}],"version-history":[{"count":9,"href":"https:\/\/yoshida-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/853\/revisions"}],"predecessor-version":[{"id":2224,"href":"https:\/\/yoshida-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/853\/revisions\/2224"}],"wp:attachment":[{"href":"https:\/\/yoshida-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=853"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/yoshida-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=853"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/yoshida-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}