Ms. Natsumi Taka and Ms. Yuumi Hatsushika (Yoshida Lab. in the Graduate School Bionics Program ) received Outstanding Performance Awards in the Consortium of Universities in Hachioji competition held on December 9 , 2017. Ms. Taka gave an oral presentation entitled “Direct Sensing of Cancer Genomic DNA for Cancer Diagnostics,” and Ms. Hatsushika gave a […]

We developed a bio-sensing system for global DNA methylation levels that can be applied to cancer diagnostics. The paper has been published in Analytica Chimica Acta (Vol. 990, p. 168-173, 2017)1. DNA methylation of cytosine in CpG dinucleotides has important biological roles in regulation of gene expression. In cancer cells, hypomethylation has been reported in […]

Yoshida W.*, Baba Y., Banzawa K., Karube I. A quantitative homogeneous assay for global DNA methylation levels using CpG-binding domain- and methyl-CpG-binding domain-fused luciferase Anal. Chim. Acta (2017) 990, 168-173

Bay D.H., Busch A., Lisdat F., Iida K., Ikebukuro K., Nagasawa K., Karube I., Yoshida W.* Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands BMC Molecular Biology (2017) 18, 17

Yoshida W.*, Baba Y., Karube I. Global DNA methylation detection system using MBD-fused luciferase based on bioluminescence resonance energy transfer assay Anal. Chem. (2016) 88, 9264-9268