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Identification of G-quadruplex clusters on human genomic DNA
We identified 9,651 G-quadruplex clusters on human genomic DNA. The paper has been published in Scientific Reports.1 G-quadruplex (G4) is a non-canonical DNA structure that has been found in several regulatory regions, such as telomeres, CpG islands and promoters. The identification of G4-forming sequences is important in elucidating the function of G4 structures on genomic […]
Our research paper about G4 clusters has been published in Scientific Reports.
Yoshida W.*, Saikyo H., Nakabayashi K., Yoshioka H., Bay D.H., Iida K., Kawai T., Hata K., Ikebukuro K., Nagasawa K., Karube I. Identification of G-quadruplex clusters by high-throughput sequencing of whole-genome amplified products with a G-quadruplex ligand. Scientific Reports (2018) 8, 3116 (*Corresponding author)
Our Students Receive Outstanding Performance Awards at the 9th Competition of the Consortium of Universities in Hachioji
Ms. Natsumi Taka and Ms. Yuumi Hatsushika (Yoshida Lab. in the Graduate School Bionics Program ) received Outstanding Performance Awards in the Consortium of Universities in Hachioji competition held on December 9 , 2017. Ms. Taka gave an oral presentation entitled “Direct Sensing of Cancer Genomic DNA for Cancer Diagnostics,” and Ms. Hatsushika gave a […]
Development of a global DNA methylation bio-sensing system for cancer diagnostics
We developed a bio-sensing system for global DNA methylation levels that can be applied to cancer diagnostics. The paper has been published in Analytica Chimica Acta (Vol. 990, p. 168-173, 2017)1. DNA methylation of cytosine in CpG dinucleotides has important biological roles in regulation of gene expression. In cancer cells, hypomethylation has been reported in […]