Development of DNA methylation level sensing system for home cancer diagnostics
DNA methylation at the 5′-position of cytosine in CpG dinucleotides has important roles in regulation of gene expression. Gene-specific DNA and global DNA methylation levels have been considered as biomarkers for cancer diagnostics. We therefore currently have several projects to develop simple DNA methylation detection systems to be applied for simple cancer diagnostics.
Functional analysis of non-canonical DNA structures in genomic DNA
DNA quadruplex structures are one of the non-canonical DNA structure that were found in genomic DNA; however, little is known about the biological functions. We are aiming to identify DNA quadruplex structures on genomic DNA by next generation sequencers and reveal the biological functions.